CBD products are generally safe to consume orally, according to a recent Validcare study. The seven-month analysis, which involved 839 participants, evaluated the impact of CBD on liver health. While there is some evidence that suggests CBD could potentially cause liver damage, the findings of the study indicate that this is not the case. In one study, rats were given high doses of CBD for seven days and it resulted in increased levels of enzymes associated with liver damage. Alcohol abuse and fatty liver diseases have been the most common chronic liver diseases and the main reasons for liver transplantation worldwide.
Cannabidiol (CBD) is a botanical component extracted from marijuana plants that does not have psychoactive effects. Previous studies have found that CBD can prevent fatty liver induced by the Lieber-Decarli ethanol diet or alcohol-free fatty liver disease (NAFLD) induced by a diet high in fat and cholesterol. The current work is an additional study on whether CBD can alleviate liver damage induced by ethanol and a diet high in fat and cholesterol (EHFD), which is a model that simulates heavy alcohol drinkers who follow a Western diet. An EHFD-induced mouse liver injury model was applied for 8 weeks to explore the protective properties of CBD and the underlying mechanisms. The results showed that CBD prevented the hepatic steatosis and oxidative stress induced by EHFD.
It also inhibited macrophage recruitment and suppressed the activation of the NFB-NLRP3-pyroptosis pathway in the liver of mice. The hepatoprotective property of CBD in this model could be due to its ability to inhibit inflammation by relieving the activation of the hepatic inflammasome and pyroptosis pathway of NFB-NLRP3. The FDA is also considering whether to approve a CBD supplement, but it's not based on science. It's important to buy your CBD products from a reputable source to ensure you're getting a quality product. A third of those who replaced a drug with CBD said the drug was a prescription anxiolytic. A recent study with mice has been in the news because it found that taking too much CBD could cause liver damage in high enough amounts. A recent study published in The Permanente Journal analyzed the effect of CBD on 72 adults with anxiety and lack of sleep. Even so, Warne called the FDA's warning words “prudent” and agreed that more research should be done on the benefits and risks of CBD.
It is not yet known whether CBD can protect liver injury induced by EHFD, and related mechanisms are unclear. In accordance with the activation of NF-1b, the EHFD diet also activated the inflammasome NLRP3 and GSDMD. CBD treatment was expected to reduce the level of NLRP3 and ASC and reduce the activation of procaspase-1 and mature IL-1beta. In addition, treatment with CBD suppressed the accumulation of hepatic lipids and attenuated oxidative stress and inflammatory response induced by excess energy in the diet (Huang et al.).However, one single study in mice has led to some scrutiny as to whether CBD oil could be harmful to the liver and affect its functioning. Rats that received CBD ate less food and gained less weight than rats that did not receive CBD. We talk about how CBD gummies and other CBD products can help improve sleep, mood, and pain levels.
They indicated that part of the hepatoprotective effect of CBD is derived from its antioxidant effect. It is important to note that CBD has been reported to exert a remarkable anti-inflammatory effect in many disorders.