Animal studies have demonstrated that extremely high doses of CBD can be damaging to the liver. The World Health Organization has confirmed this finding. However, research has also suggested that CBD oil may be beneficial for liver health due to its anti-inflammatory and antioxidant properties. Since CBD is a relatively new product, there is still much to learn about its effects, benefits, and potential risks.
A report from the California Office of Cannabis Control revealed that up to 80% of CBD products on the market had inaccurate labeling. Additionally, if CBD is sourced from low-quality hemp or processed with harsh solvents, it can cause adverse reactions. CBD does have side effects, but the real question is whether it is harmful to the liver when taken in average doses. To avoid any possible interactions between CBD and medications and to minimize liver stress, people with liver disorders should limit their use of over-the-counter (OTC) medications.
Studies have found that CBD can reduce inflammation and oxidative stress in laboratory experiments. Everyone's body is different, so it may take some time for CBD oil to reach its full potential. For those with healthy livers, there is no need to worry about buying the best CBD oils and high-quality products. A third of those who replaced a medication with CBD said it was a prescription anti-anxiety medication.
Researchers used daily doses of 1500 mg to 3000 mg of CBD to assess its safety and efficacy in humans. The goal of this study was to contribute to the body of research on hepatotoxicity related to CBD and its derivatives. It is still unclear what happens when CBD and fatty liver come into contact. Results showed that administering CBD alleviated the inflammatory response caused by EHFD.
As seen in Figure 1B, the EHFD diet caused a significant accumulation of hepatocellular lipids with an obvious infiltration of inflammatory cells in the liver of mice compared to the control group, while treatment with CBD significantly reduced lipid droplets and inflammatory lesions induced by EHFD in hepatic sections stained with H&E.