Cannabidiol (CBD) is a popular hemp supplement that has been gaining traction in recent years. But is it safe for long-term use? To date, there is no evidence of public health-related problems associated with the use of pure CBD. However, it's worth considering if CBD oil is safe for long-term use before starting any hemp supplement regimen. Research has shown that CBD oil has no toxic side effects and it's very difficult to overdose. In a phase 2 trial, treatment with up to 600 mg of CBD did not influence physiological parameters (blood pressure, heart rate) or performance on a verbal learning test.
However, no overall improvement in glycemic control was observed due to the comparatively low CBD concentrations used in the trial. In vitro studies have demonstrated that CBD inhibits the ABC transporters P-gp (glycoprotein P) and Bcrp (protein for resistance to breast cancer). Additionally, elevated levels of IL-1 beta and TNF alpha seen in transgenic mice could be reduced to wild-type levels with CBD treatment. What studies refer to as “chronic administration” of CBD only differs from acute treatment due to the repeated administration of CBD. In human SF9 cells, a CBD concentration of 0.08 μM was shown to cause the first effect, while higher doses caused a decrease in neurogenesis and cell proliferation. As an anti-inflammatory, CBD is an excellent candidate because it helps promote cellular mobility, making inflammation less serious. It also reinforces the circadian rhythm, helping people fall asleep at night and wake up feeling refreshed.
Furthermore, co-administration of fentanyl did not cause respiratory depression or cardiovascular complications during test sessions and CBD did not potentiate the effects of fentanyl. CBD could weaken the attention bias towards smoking signals or it could have interrupted reconsolidation, thus destabilizing drug-related memories. In addition, when administered every 3 days for a total of 28 weeks, almost complete reduction of metastatic nodules caused by injecting human lung carcinoma (A54) cells into naked mice was observed. Overall, research suggests that CBD oil is safe for long-term use and can be beneficial in treating certain conditions. However, more research is needed to fully understand its effects on the body.