CBD is a negative modulator of the allosteric CB1 cannabinoid receptor, which is mainly found in the brain and spinal cord. This receptor is the same one that THC binds to in order to produce its intoxicating effects. CBD can also influence non-cannabinoid receptors, such as the fifth serotonin receptor, which can be used to treat psychotic disorders, and the TRPV1 receptor, which is responsible for pain and inflammation. Studies have also linked CBD to several benefits for the heart and circulatory system, including the ability to reduce high blood pressure.
Side effects of CBD include nausea, fatigue, and irritability. It can also increase the level of anticoagulants and other medications in the blood by competing for the liver enzymes that break down these medications. While pure CBD is generally considered safe, it is not regulated at the federal level in the United States. Reputable companies like NuLeaf Naturals and Bluebird Botanicals offer batch reports on their websites and undergo testing in external laboratories.
Some studies suggest that CBD may help with substance use disorders, mental health disorders, and certain types of cancer. Epidiolex, which contains CBD, is the first cannabis-derived medication approved by the FDA for these conditions. It has been shown to reduce seizures in numerous studies, and in some cases stop them completely. CBD works differently than THC because it is a negative allosteric modulator of the CB1 receptor.
Unfortunately, many CBD products are mislabeled and some contain small amounts of THC despite claims that they do not contain THC. To understand why CBD is so effective in preventing certain diseases, we must first understand the human endocannabinoid system. CBD products derived from hemp (with less than 0.3% THC) are legal at the federal level, but may still be illegal under some state laws. Combining CBD with alcohol has recently become popular, but it is important to talk to a health professional before using a CBD product to discuss dosage and any other questions you may have.